引言当我们能够以极快的速度测序出一个又一个物种的基因组时，生命科学领域正面临着一个日益严峻的尴尬局面：我们掌握了海量的由A、T、C、G组成的生命“字母表”，却越来越难以准确读懂这些字母所拼凑出的“词汇”和“句子”。为了打破这一将基因组序列映射到生物学功能的瓶颈，3月12日《Nature ...

Platform combines proprietary AI sequence optimization, novel genetic parts, and lab validation in application-relevant cell models to improve expression and half-life, delivering top candidates in ...

《Nat. Commun》重磅：云序m7G修饰+单细胞测序破译过敏性鼻炎加重新机制！ 云序生物2025年高分RNA修饰组学文章盘点 一提到肝细胞里脂质累积，我们总会想到脂肪肝、肝纤维化乃至肝癌等严重肝脏疾病。但最新研究发现，这背后或许藏着机体自我保护的“秘密武器”。 真核细胞内存在着多种无膜细胞器，它们是生命活动时空协调的“执行者”。例如，SG在应对各种应激时迅速组装，隔离未翻译的mRNA，从而防 ...

2026年3月5日，中国科学院生物物理研究所薛愿超独立通讯在 Molecular Cell 在线发表题为 “Global mapping of circRNA-target RNA interactions reveal P-body-mediated translational repression” ...

RNA修饰研究已进入精细化解析阶段。过去二十年，表观转录组学快速发展，研究者在RNA分子中鉴定出170余种核苷水平修饰。然而，2021年一项突破性研究改变了这一研究框架——RNA不仅发生碱基修饰，还可以携带复杂的N-糖链结构。

Although there are striking differences between the cells that make up your eyes, kidneys, brain and toes, the DNA blueprint for these cells is essentially the same. Where do those differences come ...

An individual’s genome is identifiable. But datasets of RNA sequences from single cells are like a blurry photocopy of the genome. The sequence numbers are small, the data are noisy, and the sequences ...

UC Vice President for Research Patrick Limbach is a key figure in the National Academies’ massive undertaking to sequence RNA in the next 15 years. A chemist who leads the University of Cincinnati’s ...

Tina de los Reyes is the strategic biopharma development specialist for the Western US. With over 10 years of commercial experience in NGS and a Masters in Biomedical diagnostics, she specializes in ...

A team at UT Southwestern Medical Center has identified a structural trick that lets viruses translate their genetic code inside human cells, even when that code is riddled with “bad” codons the host ...