Accurate DNA replication is essential for genome maintenance. Two recent reports have uncovered new molecular mechanisms controlling the termination phase of DNA replication in higher eukaryotes and ...

DNA replication is essential to all life, yet many basic mechanisms in that process remain unknown to scientists. The structure of the replisome--a block of proteins responsible for unwinding the DNA ...

Single-molecule imaging techniques have enabled researchers to reveal the workings of the replisome, the molecular machinery that replicates DNA. A team including researchers from the University of ...

What happens to DNA replication when its components compete with other processes for access to the genome? Purified surface immobilized single GFP molecules on a slide (1). DNA replication is often ...

These cartoons show the old "textbook" view of the replisome, left, and the new view, right, revealed by electron micrograph images in the current study. Prior to this study, scientists believed the ...

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

Reactive oxygen species (ROS) were long regarded as harmful by-products of mitochondrial metabolism, but growing evidence—including our own—shows that ROS also signal to core processes such as ...

Scientists look at the base pairs that compose the "rungs" of the DNA ladder to determine a genome's sequence. The success of E. coli bacteria depends on their ability to multiply very rapidly by ...

Reactive oxygen species (ROS) were long regarded as harmful by-products of mitochondrial metabolism, but growing evidence—including our own—shows that ROS also signal to core processes such as ...