Mechanisms by which a DNA-binding protein could function as a repressor and inhibit transcription (see Milestone 2) were established by the early 1970s. For example, a repressor could bind to DNA at a ...

来自中科院遗传与发育研究所，上海药物研究所等处的研究人员发表了题为“DWARF 53 acts as a repressor of strigolactone signalling in rice”的文章，利用发现的水稻矮化多分蘖突变体e9，指出D53蛋白能作为一种抑制因素，在水稻的独脚金内酯信号途径发挥作用。 生物通报道 ...

A high throughput screen of >30,000 diverse repressor domains from across the tree of life identifies repressor domains with unique structures that underpin enhanced epigenetic effector domain potency ...

CRISPR interference (CRISPRi) is a novel method for specific gene knockdown. It's CRISPR, without the cut. The Horizon CRISPRi system uses a deactivated Cas9 nuclease (dCas9) fused to our proprietary ...