衰老的大脑以一系列分子和细胞变化为特征，这些变化被称为衰老标志。其中，以清除减少和蛋白质损伤和聚集增加为特征的蛋白质稳态（proteostasis）的下降受到了特别的关注，因为它可能是脑衰老与同样以蛋白质聚集为特征的神经退行性疾病之间的联系。大脑衰老的一个显著现象是mRNA和蛋白质水平之间的一致性丧失，因此mRNA的年龄相关变化不一定导致蛋白质水平的成比例变化。

When the concept of RNA interference was first introduced in the early 2000s, it raised the tantalizing possibility of using RNA molecules to modify human gene expression. 1 Since then, a wide range ...

RNA transcription is the genomic process in which a cell produces a duplicate of a gene's DNA sequence. In a study published in Nucleic Acids Research, University of Alabama at Birmingham Department ...