细胞衰老，最初被认为是一种肿瘤抑制机制： 当细胞遭遇不可修复的DNA损伤、端粒严重缩短或致癌信号激活时，它会选择停止分裂，进入永久性细胞周期停滞，从而避免将受损的遗传信息传递给下一代，防止癌变。

撰文丨王聪编辑丨王多鱼排版丨水成文细胞衰老（Cellular senescence）通常被定义为一种细胞状态，其特征是在没有细胞死亡的情况下细胞周期永久性停滞。衰老细胞表现出几个典型的特征，包括停止分裂状态、细胞形态改变、线粒体功能障碍、活性氧（ROS）水平升高、DNA ...

第五届单细胞与空间组学论坛2月26日，温州医科大学附属第一医院研究团队在期刊《Clinical and Translational Medicine》上发表了题为“P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis”的研究论文，本研究表明，人类血清中 ...

CCN5 reduced cardiac cellular senescence in preclinical models of cardiovascular disease. Learn how this could shape ...

New research profiles mitochondrial circular RNAs in Peripheral Blood Mononuclear Cells (PBMCs) from young and old human ...

A new research paper was published in Volume 18 of Aging-US on February 10, 2026, titled "Aging-associated mitochondrial ...

The mystery of aging has fascinated people for millennia, with many willing to do anything to halt or reverse this process, because aging is typically associated with gradual deterioration of most ...

Cellular senescence is marked by irreversible cell cycle arrest, lysosomal changes, regulatory protein expression, and SASP activation, impacting tissue health and repair. Cellular senescence is a ...

Our work highlights the need to study polyploidy and senescence in concert to understand their roles in aging, cancer, and therapeutic ...

Senescent cells, which are damaged and inflammatory, contribute significantly to aging. Researchers at the Max Planck Institute for Biology of Aging have found that worms can enter a senescent-like ...