自2009年成立发展至今，Unity一路走来备受关注。公司曾在9年时间里完成了6轮融资并于2018年成功IPO，目前共筹集了2.949亿美元资金。在一众投资者中， 世界前首富、亚马逊创始人杰夫·贝佐斯（Jeff ...

JPX通过形成BRD4-p65复合体促进内皮细胞衰老相关分泌表型（SASP），并证实Senolytics（达沙替尼+槲皮素）可有效抑制该复合体，为血管老化相关疾病的治疗提供新靶点。 血管内皮细胞衰老与JPX调控机制研究进展 （摘要部分） 该研究首次系统揭示了长链非编码RNA JPX ...

明尼苏达州罗切斯特 -- 衰老（senescent）或功能失调细胞的存在会使幼鼠加速衰老，另一方面， 在老年小鼠中使用Senolytics药物来去除这些坏细胞可以改善健康并延长寿命。 Mayo Clinic的研究人员和合作者的这些发现为这一衰老研究领域的发展奠定了基础。 该研究 ...

本综述揭示衰老免疫微环境通过细胞衰老相关分泌表型（SASP）削弱流感疫苗效果，而senolytics（如达沙替尼D+槲皮素Q）可调节CD8 T细胞免疫优势格局，虽未改善整体疫苗保护力，但为靶向衰老细胞优化老年免疫应答提供了新视角。 老龄化伴随免疫应答进行性衰退 ...

Cellular senescence refers to a state of irreversible arrest of cell proliferation. It was first described by Hayflick and colleagues in the 1960s when they observed cessation of cell proliferation ...

A new pilot study known as STAMINA (Senolytics To Alleviate Mobility Issues and Neurological Impairments in Aging), that focused on the effects of senolytic medications, Dasatinib and Quercetin (DQ), ...

“This work provides new opportunities for the development of the next generation of ChE inhibitors that specifically target AChE and BChE associated with AD pathology.” “This work provides new ...

In a recent study published in the journal Nature Aging, an international team of researchers observed that senolytics can alleviate physiologic brain aging and coronavirus disease 2019 (COVID-19) ...

Despite all the research happening around understanding Alzheimer’s disease in the past few decades, the reality is that scientists still don’t have great answers for struggling patients. This has led ...

Senolytics are an emerging class of drugs designed to target zombie-like cells that have stopped dividing and build up in the body as we age, and the past few years have seen some exciting discoveries ...

Longevity research always reminds me of the parable of blind men and an elephant. A group of blind men, who’ve never seen an elephant before, each touches a different part of the elephant’s body to ...