强大的线粒体ROS生成诱导效应T细胞端粒DNA中广泛的双链断裂（DSBs），其中DNA修复机制在呼吸爆发期间迅速被超激活以感知和连接DSBs。然而，效应T细胞是否可以利用DNA修复系统同时增强其功能激活在很大程度上仍然未知，特别是在自身免疫的背景下。

IDOR-1117-2520 is now in a Phase 2 proof-of-concept trial in psoriasis, with the potential to expand into additional autoimmune conditions where the CCR6-CCL20 pathway plays a pathogenic role.

Uveitis results from imbalance between inflammatory mechanisms and regulatory mechanisms. Several immune cells are involved in this process. The balance between T helper 17 (Th17) cells and regulatory ...