基于间充质干细胞（MSC）的治疗策略，凭借其多向分化潜能与旁分泌效应，在再生医学领域展现出巨大潜力。然而，临床转化受到细胞在损伤后恶劣微环境中存活与定植能力不足的限制，其中由细胞脱离诱导的失巢凋亡以及细胞外基质（ECM）黏附不足，严重削弱了其治疗效果。

该研究重新定义了内皮细胞WPB在凝血平衡调控中的蛋白质枢纽作用，首次阐明簇集素(Clusterin)是维持VWF多聚体功能与凝血稳态的关键调节因子。 凝血与抗凝平衡是维系内环境稳态的核心，其动态调节直接关系到血管完整性、组织修复及免疫防御功能。凝血稳态的 ...

Von Willebrand disease (VWD) is a bleeding disorder in which the blood does not clot as it should. Usually, people have VWD due to their genes, which may come from a male or female parent. Blood ...

Scientists at the RCSI University of Medicine and Health Sciences in Dublin, Ireland, have discovered a new role for the blood clotting protein, von Willebrand Factor (VWF), that could lead to the ...

The INNOVANCE ® VWF Ac assay from Siemens Healthineers is a sensitive, reliable, and convenient test system for direct, WHO-standardized determination of von Willebrand factor (VWF) activity. It ...