Xeroderma pigmentosum (XP) is a rare and devastating genetic disorder characterized by an inability to repair skin damage caused by ultraviolet (UV) light. As a result, patients with XP develop skin ...

Glasgow, UK: Xeroderma pigmentosum (XP) is a rare and devastating genetic disorder characterised by an inability to repair skin damage caused by ultraviolet (UV) light. As a result, patients with XP ...

XPC protein acts as a sensor to detect various abnormalities in the DNA structure. The faithful repair of DNA is ensured by using the basal transcription factor TFIIH and XPA protein to verify the ...

Our genomic DNA is continuously damaged by endogenous factors such as reactive oxygen species, and also by environmental factors such as ultraviolet light, radiation, and chemicals. Failure to repair ...