本研究针对生物医学研究中多种生物标志物截断点选择方法缺乏系统比较的问题，研究人员通过模拟研究和临床数据分析，比较了Youden、Euclidean、Product、Index of Union(IU)和Diagnostic Odds Ratio(DOR)五种常用方法在不同分布类型、样本量和AUC条件下的表现。研究发现，在 ...

来自多机构的研究人员针对医学诊断研究中忽略协变量影响导致评估偏差的问题，开展了基于正态误差线性回归模型的协变量调整Youden指数研究，提出了广义置信区间、贝叶斯可信区间和Bootstrap区间等多种置信区间构建方法，并通过模拟和糖尿病数据集验证了 ...

The autors present a study in 268 children (154 diagnosed with thalassemia trait and 112 diagnosed with iron deficiency anemia), ranged from 6 month to 18 years, in Pediatric Department, Clinical ...

Recently, I was engaged in an ILC (interlaboratory comparison) with a prominent signal-integrity service provider and a reputable academic research and teaching facility. The focus of the study was to ...