【编辑推荐】为解决传统显微镜检测法(FMM)在蚕业检疫中效率低、主观性强的问题，研究人员开发了靶向N. bombycis SSU rRNA基因的探针qPCR技术，灵敏度达15 fg基因组DNA，可提前13-14天检出病原体，在3616份母蛾样本中阳性符合率达93.82%，显著提升蚕种检疫效率。

家蚕感染微孢子虫N. bombycis后，Bmupp1基因通过替代剪接调控宿主抗性。研究发现Bmupp1-X2和X4在胞质中具有尿苷磷酸化酶活性，并抑制病原体增殖，而X1和X3无此功能。通过mini-gene和RNA干扰实验证实，剪接因子SC35剂量依赖性调控Bmupp1的剪接模式，其作用在感染早期和 ...

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