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8 个月
基于单细胞测序数据的G-DESC-E迭代聚类算法在泛癌关键基因分析中的 ...
本研究针对单细胞测序数据聚类准确性受批次效应和离群值影响的关键问题,开发了整合网格预处理与标签熵优化的G-DESC-E算法。通过融合KL散度与深度学习方法,在7个数据集上实现平均ARI值0.63941的聚类性能,首次鉴定出KDM5C等9个泛癌标志基因及SCG5等癌症特异性 ...
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