Wnt signals bind to Frizzled receptors to trigger canonical and noncanonical signaling responses that control cell fates during animal development and tissue homeostasis. All Wnt signals are relayed ...

As you’re holding a copy of Esquire in your well-manicured hands, I’m going to assume you understand a thing or two about looking smart and put-together. But what about looking dishevelled and elegant ...

The DEP domain of Dishevelled (Dvl) proteins transduces signals to effector proteins downstream of Dvl in the Wnt pathway. Here we report that DEP-containing mutants inhibit Wnt-induced, but not ...

Researchers have identified that Dishevelled doesn't only function in the cytoplasm and at the cell membrane – it must also pass into the nucleus. A study published today in Journal of Biology reveals ...

Everyone knows that cholesterol, at least the bad kind, can cause heart disease and hardening of the arteries. Now, researchers describe a new role for cholesterol in the activation of a cellular ...