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生物通
3 个月
EMP1通过PI3K-AKT信号通路调控三阴性乳腺癌细胞的增殖、迁移和侵袭行为
三阴性乳腺癌中EMP1低表达通过PI3K/AKT通路抑制肿瘤进展并关联患者生存预后。 三阴性乳腺癌(TNBC)作为乳腺癌中恶性程度 ...
生物通
3 个月
m6A阅读蛋白IGF2BP3通过稳定EMP1激活TGF-β通路促进胰腺癌侵袭的机制研究
本研究针对胰腺癌局部侵袭机制不清的难题,揭示了m6A阅读蛋白IGF2BP3通过识别EMP1 mRNA的m6A修饰位点增强其稳定性,进而促进 ...
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