为探究肌萎缩侧索硬化（ALS）中 TDP-43 和 FUS 细胞质包涵体（CIs）对 DNA 损伤反应（DDR）的影响，研究人员通过细胞及动物模型发现，CIs 致 ATM 过度激活、DNA 双链断裂（DSBs）积累等缺陷，而 enoxacin 激活 DICER 可恢复 DDR，为 ALS 治疗提供新方向。 在神经退行性疾病 ...

该研究以“Enoxacin shows a broad-spectrum antiviral activity against diverse viruses by enhancing antiviral RNAi in insects”为题，于2021年12月15日在线 ...

The in-vitro antigonococcal activity of enoxacin was measured by a broth microdilution method. Comparisons were made with five clinically relevant marketed drugs against 23 clinical isolates of ...

This is a preview. Log in through your library . Abstract Background and objectives: The increasing prevalence of resistant strains of Neisseria gonorrhoeae has prompted investigation of new agents ...

An FDA-approved antibiotic makes the gene-silencing technique known as RNA interference (RNAi) more effective in the laboratory, according to a new report (Nat. Biotechnol., DOI: 10.1038/nbt.1481).