Three Prime Repair Exonuclease 1 (TREX1) is an essential component of the innate immune response. It is the primary exonuclease responsible for the degradation of cytosolic DNA. The reduction of ...

When an SSB appears, polymerase epsilon approaches the nick before retracing its steps thanks to its exonuclease, allowing fork reversal to take place. The nick is repaired as an SSB, and replication ...

Homologous recombination is a DNA repair mechanism that counteracts double-stranded breaks in DNA. Researchers at Kindai University have recently revealed how the Sae2 protein coordinates with the ...

Researchers demonstrate that combinations of antiviral drugs inhibiting both polymerase and exonuclease reduce SARS-CoV-2 replication 10 times more than polymerase inhibitors alone. Researchers from ...

Researchers from Tokyo Metropolitan University have identified key factors in the mechanism behind DNA repair in our bodies. For the first time, they showed that the "proofreading" portion of the DNA ...