Germinal centers form in the body’s lymphatic tissues shortly after vaccination or infection. Once inside a germinal center, B cells undergo rapid mutations and, through a process of natural selection ...

Understanding the ways our immune response changes as we age holds the key to designing better vaccines and boosting protection for people most at risk. Research published by Dr Michelle Linterman and ...

If B cells are the munitions factories of the immune system, manufacturing antibodies to neutralize harmful pathogens, then the tiny biological structures known as germinal centers are its ...

Abbreviations: ABC, activated B-cell; CR, complete response; FISH, flourescent in situ hybridization; GC, germinal cell; GCB, germinal center B; OS, overall survival ...