Germinal centers form in the body’s lymphatic tissues shortly after vaccination or infection. Once inside a germinal center, B cells undergo rapid mutations and, through a process of natural selection ...

If B cells are the munitions factories of the immune system, manufacturing antibodies to neutralize harmful pathogens, then the tiny biological structures known as germinal centers are its ...

CAMBRIDGE, Mass. (February 18, 2016) - When it comes to selecting for B cells that produce antibodies to hostile viruses and bacteria, the immune system hedges its bets. Within the germinal centers ...

Abbreviations: ABC, activated B-cell; CR, complete response; FISH, flourescent in situ hybridization; GC, germinal cell; GCB, germinal center B; OS, overall survival ...