While proteomic analysis enables scientists to explore what goes awry in Alzheimer’s disease, most studies have focused on brain tissue, cerebrospinal fluid, or plasma, or on sporadic versus familial ...

Following on from his exposé of the dearth of specificity in our vocabulary surrounding the proteome and his emphasis that individual proteoforms should be the focus of our proteomic investigations, ...

Age is the single greatest risk factor for neurodegenerative disease, yet the cellular mechanisms that drive age-related protein accumulation in the brain remain incompletely understood. In ...

Researchers and physicians alike are interested in identifying biomarkers from minimally invasive samples like blood to aid in disease detection and monitoring. However, so far, most targets observed ...