A large proportion of the human genome consists of the repeatome, repetitive DNA sequences that are present in either tandem or interspersed configurations. There are over 1 million distinct tandem ...

It was like a map of New York missing all of Manhattan. The human reference genome finally has all its blank spots filled in, and seeing everything we missed the first time around is both ...

CHAPEL HILL, NC – In our cells, the language of DNA is written, making each of us unique. A tandem repeat occurs in DNA when a pattern of one or more nucleotides – the basic structural unit of DNA ...

First direct analysis of pathogenic sequence repeats in the human genome. Expansions of DNA repeats are very hard to analyze. A method developed by researchers at the Max Planck Institute for ...

An analysis of genetic data from over 900,000 people shows that certain stretches of DNA, made up of short sequences repeated over and over, become longer and more unstable as we age. The study found ...

Armed with base editors, scientists from the laboratory of David Liu, PhD, professor and director of the Merkin Institute of Transformative Technologies in Healthcare at the Broad Institute, and their ...

The mutation in the huntingtin (HTT) gene, which causes the incurable, dominantly inherited Huntington’s disease, was identified decades ago, following one of the most closely watched disease gene ...

Using a molecule designed to overcome a roadblock formed by a common type of genetic flaw, researchers have made progress towards novel molecular treatments for Friedreich's ataxia -- a rare but fatal ...