The structure of a key enzyme involved in protein production is revealed by cryo-electron microscopy (cryo-EM). Using cryo-EM, researchers at Goethe University (Frankfurt, Germany) shed light on ...

Archaeosine is synthesized via three steps in tRNA. ArcS, the second-step enzyme, transfers a lysine to preQ 0, which is introduced into tRNA by ArcTGT, the first-step enzyme. The resultant preQ 0-Lys ...

In all living organisms, the biomolecule transfer RNA (tRNA) plays a fundamental role in protein production. tRNAs are generated from precursor molecules in several steps. The enzyme tRNA splicing ...

A groundbreaking study has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings reveal how the absence of TRMT10A leads to a reduction in ...

Loss of TRMT10A led to a decrease in the levels of initiator methionine tRNA (tRNA iMet) and a specific glutamine tRNA (tRNA Gln). This reduction weakened the initiation of protein synthesis for ...

An international team of researchers including scientists from The Australian National University (ANU) have developed a way to reveal the smallest ...

The genetic information on DNA is transcribed into messenger RNA (mRNA) and translated to the amino acid sequence by transfer RNA (tRNA) on the ribosome. Modified nucleosides within RNA are involved ...

An international team of researchers including scientists from The Australian National University (ANU) have developed a way ...

Researchers say discoveries could expand the CRISPR toolbox and lead to more efficient, rapid diagnostic tools for detecting COVID-19, influenza, and RSV.