DNA loop extrusion is a method used to analyze how DNA is compacted into the nucleus whilst bringing regulatory elements close to protein coding genes. DNA, or deoxyribonucleic acid, is the genetic ...

Ganji M et al., and Fudenberg G et al., postulated that the SMC family of ATPases, such as condensin and cohesion, extrude DNA into large loops. Energy from ATP hydrolysis helps the SMC proteins to ...

A team of Chinese scientists has uncovered a hidden 3D structure in rice DNA that allows the crop to grow more grain while using less nitrogen fertilizer. The finding, published in Nature Genetics by ...

Scientists from the Kavli Institute of Delft University of Technology and the IMP Vienna Biocenter discovered a new property of the molecular motors that shape our chromosomes. While six years ago ...

Scientists have discovered a new property of the molecular motors that shape our chromosomes. While six years ago they found that these so-called SMC motor proteins make long loops in our DNA, they ...

Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a ...

A living cell is able to neatly package a big jumble of DNA into chromosomes while preparing for cell division. For over a century, scientists have been puzzled for decades on how the process works.

Because I find it hard to relate to something as small as the structure of the human genome, I like to imagine it scaled up a millionfold. At this size, each DNA molecule—a chromosome—is as wide as a ...

In mammalian genome, enhancers are sequences that are often far away from their target genes. They play a key role in transcription regulation through long-range DNA loops. It is now widely accepted ...