VESALIUS-CV is a large (N=12 257), rigorously conducted, international, randomized, placebo-controlled trial conducted in patients at high cardiovascular risk but without prior myocardial infarction ...

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The arterial vasculature is the second most frequently calcified structure in the human body after the skeleton. Calcification of the aorta and aortic valves occurs in most individuals in westernized ...

High-quality mechanistic and clinically relevant science to keep clinicians at the forefront of the latest advancements in the diagnosis and treatment of heart failure ...

Coronary artery disease causes acute myocardial infarction, making it one of the leading causes of mortality and morbidity worldwide. An acute coronary artery occlusion can result in the death of a ...

Bilingualism has been associated with slower cognitive aging and a later onset of dementia. In this study, we aimed to determine whether bilingualism also influences cognitive outcome after stroke.

BACKGROUND: Aortic valve calcification increases leaflet stiffness and contributes to the development of calcific aortic valve disease. The molecular and cellular mechanisms underlying calcification ...

Myocarditis has been recognized as a complication of COVID-19 mRNA vaccinations, particularly in adolescent and young adult male patients. 1 Cardiovascular sequelae after an acute episode of ...

These results provide the first in vivo validation that Tnpo3 overexpression restores alternative splicing and cardiac dysfunction in 2 patient-relevant RBM20-DCM models with no observed adverse ...

Little DT, Howard CM, Pendergraft E, Brittian KR, Audam TN, Lukudu EW, Smith J, Nguyen D, Nishida Y, Yamaguchi Y, et al. Activated cardiac fibroblasts are a primary source of high-molecular-weight ...

BACKGROUND: Forecasts for the future prevalence of cardiovascular disease and stroke are crucial to guide efforts to improve health outcomes across the life course for women. METHODS: Using historical ...

Immune checkpoint inhibitors (ICIs) have transformed oncology care by unleashing T-cells to achieve antitumor effects but can cause inflammatory adverse events including myocarditis. 1 ICI-myocarditis ...