reactivity depends on both the N terminus (amino acids 7–9), and an amino acid sequence of tau (amino acids 313–322) in the third microtubule binding domain. Recognizes neurofibrillary tangles but ...

Oregon Health and Science University 3181 SW Sam Jackson Park Road Mail Code CR 131 Portland, OR97239 United States Visit Website Contact: Jeffrey Kaye, M.D. Phone: 503-494-6976 Fax: 503-494-7499 ...

PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...

A bad bout with pneumonia can do more than mess with the lungs—it can also hasten cognitive decline and even the onset of Alzheimer’s disease. While the mechanisms at work in this double whammy remain ...

The 17q21.31 microduplication is a copy number variant encompassing the CRHR1, MAPT, STH, and KANSL1 genes. Clinical phenotypes similar to Alzheimer's disease (AD) have been reported in several ...

On November 24, Novo Nordisk announced that the GLP-1 mimetic semaglutide had failed to slow progression of Alzheimer’s disease in two Phase 3 trials. Even though the cat was out of the bag, ...

Dozens of rodents have been generated that model various aspects of ALS, like motor impairment or degeneration of motor neurons. No model recapitulates the human disease perfectly. By organizing ...

Cerebral small vessel disease is an umbrella term for disorders that cause the brain’s small blood vessels to stiffen, narrow, clog, or leak. cSVD increases a person’s risk for stroke and is a common ...

Currently, hopes for an Alzheimer’s prevention therapy hang on BACE inhibitors that squelch generation of Aβ peptides. When these compounds failed to slow cognitive decline in symptomatic patients, ...

In mice, data suggest that tau seeds sneak across synapses, spreading tangle pathology throughout the brain. Is the same true in people? Quite likely, say scientists led by Tara Spires-Jones, ...

To mark the 20th anniversary of Alzforum's launch in 1996, we have compiled a timeline reflecting the evolution of Alzheimer’s disease research, starting from Alois Alzheimer's public presentation of ...