Wortmannin（渥曼青霉素，AbMole，M2053）是一种源自真菌的甾体代谢物，作为磷脂酰肌醇3-激酶（PI3K）家族的强效共价抑制剂，能不可逆地结合PI3K催化亚基。Wortmannin还能抑制同属PI3K家族的DNA依赖性蛋白激酶（DNA-PK）和共济失调毛细血管扩张症突变激酶（ATM）。在生物学活性上，Wortmannin（渥曼青霉素，AbMole，M2053） ...
Antioxidant-1 may promote HCC carcinogenesis through the activation of the c-Myb/PI3K/AKT pathway and the inhibition of copper accumulation and oxidative stress. Despite advancements in diagnostic and ...
A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...
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