This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major ...

We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial. Adult patients with Covid-19, within 24 hours after starting organ support in the intensive ...

For doctors, there are rarely easy decisions to be made when it comes to the care of someone who is critically ill. In some cases, a bleak prognosis may require them to advise a patient against ...