在这里，研究人员采用谱系追踪和数学模型来研究内皮蛋白C受体 (EPCR)高的HSC在5-氟尿嘧啶 (5-FU)诱导的骨髓消融后的细胞命运动力学。该研究分析揭示了5-FU治疗后HSC分化的短暂激增，主要产生髓样多能祖细胞 (MPPs)——在稳态条件下通常接受有限HSC输入的亚群。 在这种最初的细胞命运转换之后，HSC分化持续升高，但很快恢复到在未受干扰的造血中观察到的稳态分化模式。此外，数据强调了5 ...

Single-cell transcriptomics data from mouse bone-relevant cells was used to inform human bone mineral density genome-wide association studies and prioritize genetic targets with potential causal roles ...

Understanding how cells transform into specialized types during human development is a central challenge in biology. This complex process, known as cell differentiation, holds the key to understanding ...

A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...

The cancer stem cell (CSC) paradigm is pivotal for understanding tumor progression, relapses, and therapeutic failure. Endowed with self-renewal, ...

How do stem cells know what to become? Nearly three decades after scientists isolated the first human embryonic stem cells, researchers are still working hard to understand precisely how a single, ...

From axolotls to zebrafish, stem cells possess remarkable regenerative abilities, enabling them to restore lost limbs and repair damaged organs. These extraordinary capabilities, however, are not ...