在这里，研究人员采用谱系追踪和数学模型来研究内皮蛋白C受体 (EPCR)高的HSC在5-氟尿嘧啶 (5-FU)诱导的骨髓消融后的细胞命运动力学。该研究分析揭示了5-FU治疗后HSC分化的短暂激增，主要产生髓样多能祖细胞 (MPPs)——在稳态条件下通常接受有限HSC输入的亚群。 在这种最初的细胞命运转换之后，HSC分化持续升高，但很快恢复到在未受干扰的造血中观察到的稳态分化模式。此外，数据强调了5 ...

T cell development is a tightly regulated process that transforms immature thymocytes into mature T cells with distinct functionalities. In the thymus, precursor cells undergo a series of selection ...

Understanding how cells transform into specialized types during human development is a central challenge in biology. This complex process, known as cell differentiation, holds the key to understanding ...

The sugar glucose, which is the main source of energy in almost every living cell, has been revealed in a Stanford Medicine study to also be a master regulator of tissue differentiation - the process ...

Single-cell transcriptomics data from mouse bone-relevant cells was used to inform human bone mineral density genome-wide association studies and prioritize genetic targets with potential causal roles ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

A comprehensive map of aberrant hematopoiesis in people with acute myeloid leukemia defines specific cell states and potential therapeutic targets. The team used their reference map for normal ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...