Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 ...

Explore the latest colorectal cancer treatment advances, from precision oncology and immunotherapy to ADCs, bispecifics, and T-cell engagers.

EGFR-positive lung cancer is more common in non-smokers (particularly those with adenocarcinoma) and younger adults, as it often develops from a single genetic mutation rather than widespread DNA ...

Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 ...

双去甲氧基姜黄素 (BDMC) 是一种天然姜黄素类化合物，其溶解度和稳定性均高于姜黄素，但其在寿命和健康寿命调控中的潜在作用仍未得到充分研究。 2026年3月10日，来自天津医科大学的研究团队在 Food & Function 杂志发表题为“Bisdemethoxycurcumin extends lifespan and healthspan in Caenorhabditis elegans ...

Global breast cancer incidence continues to rise and researchers have reported that nanoformulations of curcumin may overcome longstanding bioavailability barriers to enhance antitumour efficacy, ...

Second clinical candidate from HUTCHMED’s next-generation ATTC platform —— Leveraging synergy through simultaneous inhibition of PAM pathway and EGFR signaling — Hong Kong, Shanghai & Florham Park, NJ ...

醛固酮失调被认为是难治性高血压发病机制中的重要因素，其特征是相对于钠平衡而言醛固酮分泌不当升高。既往研究表明，药理学阻断醛固酮信号通路可有效降低未控制或难治性高血压患者的血压。Bax24试验作为完全独立的3期研究，与此前报道的BaxHTN试验相互印证 ...

C3 glomerulopathy (C3G) and immune complex membranoproliferative glomerulonephritis (IC-MPGN) are rare and progressive kidney diseases that often lead to kidney failure. Both involve overactivity in ...

Independent Data Monitoring Committee Recommends Discontinuation of Phase III Trial Following Futility AnalysisSYDNEY, AUSTRALIA, March 13, 2026 ...