Spinal cord injury often triggers a cascade of secondary damage that severely limits functional recovery, largely driven by ...

Background Concomitant metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in patients with chronic ...

Sepsis remains a major challenge in modern medicine, claiming millions of lives each year. For decades, clinical management has largely focused on suppressing excessive inflammation.

Endoplasmic reticulum (ER) stress and the unfolded protein response are often implicated in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), from simple steatosis ...

Fat-based vesicles help deliver GM1 to the brain, improving movement and extending survival in mouse models of ALS, a study finds.

A secondary stress signaling pathway in the response to optic axon injury is an unexpectedly strong contributor to both neurodegeneration and axon regenerative potential.

A study on worms led by researchers from Vanderbilt University School of Medicine in the US has uncovered a previously unknown adaptation to aging that actively remodels one of the largest and most ...

Yeast, worms, and mice remodel their endoplasmic reticulum early in the aging process. The protective shift offers potential targets to extend healthy lifespan.

A researcher at the University of Missouri has made a promising breakthrough in the quest to help people with amyotrophic ...

Dendritic cells (DCs) are increasingly recognized as important contributors to sepsis-associated immune dysfunction. As professional antigen-presenting cells, they bridge innate sensing and durable ...

Researchers demonstrated that GM1 encapsulated in lipid nanoparticles can cross the blood-brain barrier and improve motor ...