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Nature Biotechnology | 重塑免疫防线:突破重围的肿瘤新生抗原疫苗将 ...
引言在过去的一个多世纪里,我们试图通过疫苗来治疗癌症的尝试屡屡受挫。然而,近年来基因组测序技术的飞跃、人类白细胞抗原(HLA)I类表位预测算法的大幅优化,以及强大的抗原递送平台的崛起,将这一曾经饱受质疑的治疗理念推向了肿瘤学研究的最前沿。当我们审视肿瘤细胞的演化过程时,其基因组的异常转录和翻译会产生带有 ...
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