Defects in the gene encoding β-globin, a component of adult haemoglobin, cause β-globinopathies such as sickle cell disease and β-thalassaemia. Disease symptoms can be alleviated by the induction of ...
THE typical case of spontaneously occurring pyridoxine-responsive anemia in human beings has been characterized by hypochromic, microcytic red cells, normoblastic proliferation in the bone marrow, ...