Ongoing threats from infectious diseases such as pandemic influenza, as well as the promise of emerging immunotherapies, are driving the demand for new vaccine platforms. Although traditional protein ...

There are 11 human cysteine cathepsins, which primarily function as endopeptidases within endolysosomal compartments. Specific cysteine cathepsins have extracellular functions, for example, cathepsin ...

Background Obesity is associated with accumulation of macrophages in white adipose tissue (WAT), which contribute to the development of insulin resistance. Germ-free (GF) mice have reduced adiposity ...