体液免疫记忆是疫苗发挥长期保护作用的核心，长寿浆细胞（LLPCs）作为抗体的主要分泌细胞，其在骨髓中的存活与维持是体液免疫记忆的关键，而调控该细胞寿命的分子机制此前尚未明确。间歇性饮食作为一种常见的生理应激方式，被证实能调控先天和适应性免疫细胞功能，但其对长寿浆细胞存活及疫苗诱导的保护性抗体持续时间的影响，一直是领域内的未知问题。 图 1：文章来源（Immunity） 2026 年 2 月 23 ...

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