T cells are highly adaptable white blood cells that protect us from infections, cancer, and other threats. To do their job, T cells must rapidly switch from a quiet resting state to an active, energy ...

In 1985, the Nobel Prize in Physiology or Medicine was awarded to Michael Brown and Joseph Goldstein for identifying the receptor that clears LDL particles from the bloodstream. High blood levels of ...

Professor Gilbert Thompson, who has died aged 93, played a leading role in showing how “bad” cholesterol (low-density lipoprotein or LDL cholesterol) is processed by the body and how faults in this ...

Proprotein convertase subtilisin/kexin type-9 (PCSK9) is highly expressed in adult hepatocytes. PCSK9 binds to and promotes the degradation of the low-density lipoprotein (LDL) receptor, thereby ...

Alumni Endowed Professor of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine RNA viruses use a ...

Heart disease remains the world's leading cause of death, and elevated LDL cholesterol is one of its biggest drivers. Cardiovascular disease remains the leading cause of death worldwide, with elevated ...

Findings showed the trial met the primary endpoint, with enlicitide demonstrating a statistically significantly meaningful reduction in LDL-C compared with placebo. Topline data were announced from a ...

Researchers have announced a promising new oral medication capable of slashing harmful cholesterol more powerfully than standard statins, a potential breakthrough for more than 86 million Americans if ...

High levels of low-density lipoprotein (LDL) cholesterol can cause artery blockages and diseases like heart attacks and strokes. Further, it raises the risk of cardiovascular disease (CVD). Thickened ...