Hematopoietic stem cells (HSCs) emerge in vertebrate embryos under the coordinated regulation of multiple signaling pathways. Despite advances in developmental biology, robust protocols for generating ...

Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

The Notch gene was first described and named in the 20th century by the American scientist Dexter J. Colman through the study of the Notch wing mutant in Drosophila melanogaster (1). Subsequently, ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Cells change their identity through the Notch signaling pathway, which alters gene expression. Notch alters gene expression by forming a heterotrimer composed of three proteins: CSL, RAMANK, and MAML.

The Notch signaling pathway plays important roles in many developmental and disease processes. Although well-studied there remain many puzzling aspects. One is the fact that as well as activating the ...

Prostate cancer, especially in advanced stages such as castration-resistant prostate cancer, is challenging to treat. Traditional therapies targeting androgen receptor (AR) signaling have limited ...