Vascular calcification, low bone mass and fragility fractures are all frequent age-dependent disorders. Recent clinical and experimental data suggest that vascular calcification and bone loss could ...

Osteoblasts with reduced expression of SIRT7 show markedly reduced calcification (stained red) compared to normal osteoblasts. Introduction of a mutant SP7/Osterix, which deacylated the 368th lysine ...

The bone marrow serves as the main site of hematopoiesis in humans, giving rise to red and white blood cells. This space is highly organized into distinct regions, or niches, that perform different ...

The ionic and metabolic impairment observed in chronic kidney disease (CKD) leads to vascular calcification, which can induce cardiovascular events and mortality. Several factors may impact the ...

Promising therapies still need to be further evaluated in clinical trials. The first systematic review of trials of possible therapies to slow vascular calcification in chronic kidney disease (CKD) ...

Yabing Chen, Ph.D., has been awarded two National Institutes of Health grants totaling more than $5 million to further her research into vascular diseases ranging from hardening of the arteries to ...