Isoprenoid biosynthesis is a fundamental metabolic process that produces a vast array of naturally occurring compounds essential for cellular structure and function. In most eukaryotes, the mevalonate ...

Researchers have discovered that activating the pentose phosphate pathway makes antitumor CD8+ T cells more likely to stay in an immature, stem-like, “precursor” state. Combining this metabolic ...

Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy, according to a preclinical study. The findings ...

A new study delving into the genetic drivers of a rare and aggressive childhood cancer called Malignant Peripheral Nerve Sheath Tumor (MPNST) has revealed metabolic frailties in the cancer cells that ...

In a new study published in Nature Metabolism titled “Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction,” researchers from the Buck ...

CKD and VHD share metabolic, inflammatory, and fibrotic pathways, worsening each other's progression and complicating management. An integrated care model involving nephrologists, cardiologists, and ...