Phosphorylation Regulation

Cancers Have a Unique "Fingerprint" of Enzymes Interacting With DNA

Researchers identified more than 200 metabolic enzymes attached to human DNA, forming unique nuclear metabolic fingerprints across tissues and cancers.

Science Daily

Hidden metabolism found operating inside the cell nucleus

Researchers have found hundreds of metabolic enzymes attached to human DNA inside the cell nucleus. Different tissues and cancers show unique patterns of these enzymes, forming a “nuclear metabolic ...

BioTechniques

First evidence of cancers’ unique nuclear metabolic fingerprints

Researchers have found evidence of nuclear metabolic enzymes for the first time, contributing to our understanding of cancer ...

AZoLifeSciences on MSN

Discovery of nuclear metabolic fingerprints offers new insights into cancer

More than two hundred metabolic enzymes, many of which are normally tasked with producing energy in the mitochondria, are also found sitting directly on top of human DNA, according to a study ...

腾讯网

AbMole丨Wortmannin（渥曼青霉素）：强效PI3K家族抑制剂，在信号转导 ...

Wortmannin（渥曼青霉素，AbMole，M2053）是一种源自真菌的甾体代谢物，作为磷脂酰肌醇3-激酶（PI3K）家族的强效共价抑制剂，能不可逆地结合PI3K催化亚基。Wortmannin还能抑制同属PI3K家族的DNA依赖性蛋白激酶（DNA-PK）和共济失调毛细血管扩张症突变激酶（ATM）。在生物学活性上，Wortmannin（渥曼青霉素，AbMole，M2053） ...