本研究揭示了MYC癌蛋白作为RNA结合蛋白的新功能：在转录应激下，MYC从DNA转向结合新生RNA，通过其RNA结合区域RBRIII形成多聚体，募集核外泌体复合物降解双链RNA和R-loop衍生的RNA-DNA杂合体，从而抑制TLR3-TBK1天然免疫信号通路，促进肿瘤免疫逃逸。这项工作阐明了MYC ...

本刊编辑推荐：针对R-loop引起的不可修复DNA损伤在模式生物中的监测机制这一关键问题，研究者通过构建rnh-1.0 rnh-2 M-/Z-双缺失突变体等遗传工具，首次揭示秀丽隐杆线虫生殖系中特殊DNA损伤逃逸检查点检测的分子机制，为理解基因组稳定性维持提供了新视角。

Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In this ...

This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, ...

This study is achieved by Professor Wei Xu’s research team from Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences. The research team established mDRIP-seq, a ...

Image Caption: The factors contributing to R-loop formation. Several factors contribute to R-loop formation, including RNA components, specific DNA structures, histone and RNA modifications, ...

Kyle Miller and his team discovered a potential new target for drug therapies: structures in our DNA called R-loops. A human cancer cell that overexpresses the enzyme APOBEC3B (left) has fewer R-loops ...

New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli. Genetically speaking, it's a bacterium's worst-case scenario: during transcription, newly minted RNA sticks to ...