RecBCD酶中RecB的nuclease域通过allosteric机制调控DNA结合亲和力及碱基对熔解过程，冷冻电镜结构显示RecBΔNucCD结合后仅熔解4 bp，较RecBCD的11 bp减少，且RecB_Nuc的缺失导致RecD亚基构象异质性增加。 ### RecBCD酶及其变体RecBΔNucCD在DNA双链断裂修复中的作用机制解析 #### 1 ...

A DNA sequence that acts as a throttle to control the rate at which an enzyme moves along the DNA has been observed by researchers at UC Davis. By controlling the activity of the RecBCD helicase ...

Breaks in our genetic code termed “DNA double-strand breaks” create cellular stress and cell death if not rapidly repaired. Environmental mutagens including UV light can cause DNA breaks, and these ...

In this issue, Wu et al. show that the RecBC helicase, which is involved in repairing double-strand DNA breaks, uses one ATPase motor to drive two translocases along opposite strands of DNA—much as an ...

RecBCD, an enzyme that unwinds the DNA double helix so that it can be copied or repaired, is powered by two motor units that run in opposite directions, according to a report by UC Davis researchers ...

A DNA sequence that acts as a throttle to control the rate at which an enzyme moves along the DNA has been observed by researchers at UC Davis. By controlling the activity of the RecBCD helicase ...

Experiments by biochemists at the University of California, Davis show for the first time that a law of physics, the ergodic theorem, can be demonstrated by a collection of individual protein ...