A receptor involved in normal physiological processes may also drive breast cancer growth when overexpressed.

Compounds that bind to the intracellular core of G-protein-coupled receptors can encourage interactions with some G proteins and prevent them with others, leading to a switch in downstream signalling ...

The human P2X4 receptor plays an important role in chronic pain, inflammation and some types of cancer. Researchers at the University of Bonn and the University Hospital Bonn (UKB) have now discovered ...

A study carried out by the University of Bonn and the University Hospital Bonn throws light on how an important receptor can be inhibited. The human P2X4 receptor plays an important role in chronic ...

New research combines two powerful imaging techniques to study the complete structure of a common aGPCR, including how its long and complex extracellular region interacts with the transmembrane region ...

Researchers examine the thermodynamic properties of the interaction of the histamine H1 receptor with geometric isomers of the antihistamine drug doxepin Recently, the importance of drug design based ...

Neuroinflammation drives the progression of neurodegenerative disorders like Alzheimer's, Parkinson's, and multiple sclerosis ...

Our noses can effortlessly distinguish the aroma of coffee from the tang of gasoline, yet how they do it has long been a mystery. In a study that appears Oct. 30 in Nature, scientists at Duke ...

As key molecules on the surface of immune cells, Fc receptors are the core hub of antibody-mediated effector functions. They play an irreplaceable role in physiological processes such as ...

New therapy uses synthetic nanofibers to mimic the natural signaling of a protein that is crucial for cartilage formation and maintenance. Researchers found that intensifying the motion of molecules ...

Research Compounds Scientists Study for Brain Function and Cognitive Performance Modern neuroscience research continues ...