A holistic inquiry into how toxic tau impacts synapses provides a new take on the processes that lead to neuronal dysfunction and memory loss in Alzheimer’s disease. A tool, developed in the Tracy lab ...

Abstract: Action-Potential-mediated release of neurotransmitters at chemical synapses is fundamental to interneuronal communication. More specifically, presynaptic Action Potentials (APs) trigger the ...

This study presents a valuable finding on the molecular mechanisms that govern GABAergic inhibitory synapse function. The authors propose that Endophilin A1 serves as a novel regulator of GABAergic ...

Summary: Researchers discovered that gephyrin, a key protein at inhibitory synapses, forms organized filaments that act as the structural basis for postsynaptic densities. This finding overturns ...

Summary: New research uncovers how tau pathology spreads and damages synapses in progressive supranuclear palsy (PSP). Using human postmortem tissue and live brain slice models, scientists showed tau ...

The human brain contains nearly 86 billion neurons, constantly exchanging messages like an immense social media network, but neurons do not work alone – glial cells, neurotransmitters, receptors, and ...

Royalty-free licenses let you pay once to use copyrighted images and video clips in personal and commercial projects on an ongoing basis without requiring additional payments each time you use that ...

During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...

'minis' is a software for electrophysiological data analysis. It allows you to detect and analyse spontaneous postsynaptic potetnials/currents in whole-cell patch clamp recordings and to estimate the ...

Copyright: Crown Copyright © 2025 Published by Elsevier B.V. Synapse preservation is key for healthy cognitive ageing, and synapse loss represents a critical ...

For unsuspecting depositors of online financial start-ups, the unraveling of a little-known intermediary has separated them from their life savings. By Rob Copeland Rob Copeland covers Wall Street and ...