为了研究这个问题，Finley的团队敲除了TCA循环中的一种酶，造成代谢瓶颈，导致循环的起始代谢物柠檬酸积累。研究人员发现，柠檬酸的积累表明营养物质的摄入超过了细胞的需求，从而引发应激反应。当他们敲除TCA循环中的第二种酶——即产生柠檬酸的酶时，细胞恢复正常生长，尽管通过TCA循环产生的能量受到了干扰。结果表明，防止柠檬酸积累的能力，无论是通过快速清除柠檬酸还是避免产生柠檬酸，是保持细胞健康的关键 ...

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Lysosomes were once viewed mainly as cellular waste disposers, but are now recognized as key hubs for nutrient sensing and metabolic signaling.

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New research profiles mitochondrial circular RNAs in Peripheral Blood Mononuclear Cells (PBMCs) from young and old human ...

New research from Memorial Sloan Kettering Cancer Center (MSK) finds the TCA cycle’s waste-management function may present an opportunity against cancer; shows how microplastics impair immune ...