Something happens when a rat starts running. Not just the obvious things, the faster heart, the warming muscles, the rhythmic percussion of paws against the wheel. Something quieter. Something that ...

Voluntary exercise reshapes gut microbiota and tryptophan metabolism, with consequences for the hippocampus, the ...

The peer-reviewed research article in Brain Medicine titled "Exercise induces changes in tryptophan metabolism by gut microbes associated with hippocampal function in adult rats," is freely available ...

Exercise can be a powerful tool to improve symptoms of anxiety and depression. The amino acid tryptophan may be part of the ...

Elevated tryptophan metabolism correlates with improved csDMARD response, reduced inflammation, and better clinical outcomes in rheumatoid arthritis patients. Multiomics analysis identified ...

This review synthesizes progress in pathway optimization, regulatory rewiring, and microbial cell factory design that has driven L-Trp titers to industrially relevant levels while enabling the ...

The connection between diet and mental wellness has gained increasing attention in recent years, with certain nutrients emerging as key players in brain health. Among these, tryptophan stands out as a ...

As people grow older, the same brain chemistry that once supported sharp thinking and stable mood can quietly start to work against them. A new wave of research is revealing how a single amino acid, ...

Researchers at UT Southwestern Medical Center have discovered that a diet free of the amino acid tryptophan can effectively halt the growth of liver cancer in mice. Their findings, published in Nature ...

Microbiome dysbiosis—changes in the composition of gut microbes that alter the metabolites present—has long been implicated in playing a causative role in the pathophysiology of autism spectrum ...