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多能性阶段基因表达谱可预测iPSC克隆的胰腺内分泌分化潜能
iPSC来源的β细胞是1型糖尿病细胞替代疗法的希望,但克隆分化能力参差不齐,筛选耗时耗力。本研究通过转录组学分析,成功在多能性阶段就鉴定出一个能够预测克隆向胰腺内分泌(特别是胰岛素产生细胞)分化效率和功能的基因表达特征。这为早期、快速筛选 ...
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