A new method enables engineered immune progenitor cells to replace microglia in mice and reveals how a genetic mutation can lead to inflammation in the brain.
When the digestive system fails to absorb fructose, the lingering sugar disrupts the gut microbiome. A recent study reveals this bacterial shift sparks low-grade, body-wide inflammation that can alter ...
Scientists have developed a promising new approach to treating Alzheimer’s disease by turning ordinary brain cells into powerful plaque-clearing machines. Instead of requiring frequent antibody ...
Neuropathic pain is a devastating type of pain that significantly reduces the quality of life of affected people.
Molecular profiles of oligodendrocytes and microglia in rhesus monkeys that followed a lifelong 30% calorie restriction diet suggested that restricting food intake may protect against myelin pathology ...
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你小时候的记忆去哪了?真的被大脑删除了吗?答案出乎意料
第一次走路、第一次说话、第一次感到恐惧,这些相关的记忆似乎全都消失了。长期以来,主流观点认为婴儿无法保存记忆,因为他们的大脑尚未成熟。1月20日,在发表于《公共科学图书馆·生物学》的一项研究中,科学家通过一种巧妙的方法,成功让幼年小鼠的记忆保留到了成年 ...
LDC7559(AbMole,M13554)是一种泛凋亡(PANoptosis)相关分子消皮素 D (GSDMD) 的抑制剂,最初通过从化合物库中筛选抑制佛波酯(Phorbol 12-myristate 13-acetate,PMA)诱导的中性粒细胞胞外杀菌网络(NETosis)而被发现,它在PMA诱导的NETosis中IC50约为5.6 μM,在胆固醇晶体诱导的NETosis中IC50约为300 ...
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