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生物通
9 个月
氢可的松经毛霉生物转化及其代谢物对 11β- 羟基类固醇脱氢酶 Ⅰ 型 ...
为探究微生物转化类固醇的潜力及代谢物抗 2 型糖尿病(T2DM)作用,研究人员开展毛霉(Mucor hiemalis)对氢可的松的生物转化研究。通过 9 天培养获主要代谢物,经鉴定及分子对接、药代动力学分析,发现其与 11β- 羟基类固醇脱氢酶 Ⅰ 型(11β-HSD1)有结合潜力 ...
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