Control of spindle orientation is a fundamental process for embryonic development, morphogenesis and tissue homeostasis, while defects are associated with tumorigenesis and other diseases. Force ...

In a recent study posted to the medRxiv* pre-print server, a team of researchers demonstrated the inhibitory action of integrin/transforming growth factor beta 1 (TGF-β1) inhibitor GLPG0187 on severe ...

In a recent study published in the Proceedings of the National Academy of Sciences Journal, researchers examined the therapeutic effects of targeting integrins for treating Amyotrophic lateral ...

Johns Hopkins University biologists have found that a protein that plays a key role in the lives of stem cells can bolster the growth of damaged muscle tissue, a step that could potentially contribute ...

At last, the researchers have defined the molecular basis of the cell membrane in integrin activation. Scripps Research scientists have uncovered the workings of a critical process in cell survival.

The tissue in our body can only hold together if the cells adhere not only to each other, but also to extracellular structures, such as collagen fibers of the connective tissue and the skin. How ...