Cell–extracellular matrix (ECM) interactions are mediated through specialized subcellular sites that contain specific adhesion receptors, cytoskeletal elements and a wide variety of inter-connecting ...

Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical-stage biotechnology company focused on the discovery and development of integrin-based therapeutics, today provided a corporate update and reported ...

Pliant Therapeutics (NASDAQ:PLRX) used its presentation at Oppenheimer’s 36th Annual Healthcare Conference to outline its ...

Tumor necrosis factor-α-induced protein-8 like-2 suppressed the proliferation, migration, and invasion of cholangiocarcinoma cells.

PLN-101095 Phase 1 data showed deep and durable ongoing responses in checkpoint inhibitor refractory solid tumors PLN-101095 accelerated development plan underway with initiation of Phase 1b indicatio ...

Atherosclerosis represents a chronic inflammatory disease characterized by the accumulation of lipid-laden macrophage foam cells within arterial ...

纤维连接蛋白作为细胞外基质的核心组分之一，其表达调控机制与细胞骨架动态重组之间存在何种分子关联，这一问题在既往研究中尚未得到充分阐明。近期一项整合动物模型与体外细胞学实验的研究，系统揭示了Cdc42效应蛋白家族成员Cdc42ep1在TGF-β诱导的上皮 ...

如今，许多癌症患者拥有比过去更多的治疗选择。然而，对于某些癌症，如胰腺癌，手术和化疗仍然是仅有的可用疗法。加州大学圣地亚哥分校的癌症生物学家Tatiana Hurtado de ...

Researchers from The University of Osaka find that chronic liver congestion is linked to severe liver diseases through a specific signaling pathway in ...

An integrin mutation impairs skin T cell migration, enabling HPV proliferation that causes warts and lesions in a rare genetic dermatological condition.

Explore the serious implications of liver congestion and its connections to fibrosis, cirrhosis, and liver cancer in recent ...